Our laboratory uses systems biology principles to elucidate and then investigate cell regulatory networks. We are particularly interested in applying this perspective to understand cancer tumorigenesis, drug resistance, and cellular heterogeneity, and are working with clinical researchers at Columbia University Medical Center to conduct N-of-1 clinical trials for precision cancer medicine. We also use systems biology approaches to characterize drug synergies and mechanisms of action, and to investigate other biological phenotypes, especially related to neurodegenerative diseases and stem cell differentiation.