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http://califano.c2b2.columbia.edu/news/2016/1/29/clinical-trials-for-cancer-one-patient-at-a-time monthly 0.5 2016-02-02 http://califano.c2b2.columbia.edu/read-me daily 0.75 2016-01-23 http://califano.c2b2.columbia.edu/dissection-of-other-biological-phenotypes daily 0.75 2016-04-06 https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/1454413218168-NSR45CJ2LGKAJC3INMZS/image-asset.jpeg Dissection of Other Biological Phenotypes Using MARINa, our lab developed a context-specific brain regulatory network and identified master regulators of the dopaminergic stress response. This strategy could also be used to uncover molecular determinants of other neurodegenerative phenotypes. http://califano.c2b2.columbia.edu/modeling-cell-regulatory-networks daily 0.75 2016-04-20 https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/1454405594053-4DM6DS997PS7ZST57L2T/image-asset.jpeg Modeling Cell Regulatory Networks Transcriptional regulatory module controlling the mesenchymal signature of high-grade glioma, computationally inferred and validated by biochemical and functional assays. http://califano.c2b2.columbia.edu/cancer-systems-biology daily 0.75 2016-04-20 https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/1454402856056-TFOJLGN4ASLBPN5A707P/bottlenecks+copy.jpg Cancer Systems Biology Schematic representation of how cancer bottlenecks channel upstream genetic alterations to initiate cancer driving programs. http://califano.c2b2.columbia.edu/publications daily 0.75 2025-10-08 http://califano.c2b2.columbia.edu/andrea-califano daily 0.75 2019-03-22 https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/1454065457352-Q9EFYY8LV7AP0HG4ZXZG/image-asset.jpeg Andrea Califano http://califano.c2b2.columbia.edu/people daily 0.75 2026-01-20 https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/17f0b772-1534-4d8d-bbc4-b31e381e56f5/Andrea++Picture+B.jpg People https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/251aece2-e0b4-4c66-bc54-0ecc3d0b0ff8/Cristina+picture+B.jpg People https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/c36532da-1835-4e11-b39f-8a0667a05a04/Grace+Chen+3.jpg People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/aa30e10b-63d5-4955-98e0-fc530b23e9b1/Edited_Catherine+Yinging+Chen%2C+GRA+%282024-%29.png People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/bf23852f-8b6e-4fd6-85d8-3451d5e29484/Leo+Dupire+C.jpg People https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/b4d2fc44-517d-44bb-8f86-482c1f436a01/Melania+Franchini+PictureB.png People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/c1f58e86-0584-42be-801f-a7615ac0349b/Adina+Grunn+C.jpg People https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/a962039e-ae0e-4cf2-b405-ed3afb898797/IMG_1172.jpeg People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/3d449ba7-dbbb-4b61-87b7-b6f3eb25aedb/Hu%2C+Lucas.jpg People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/8991c762-62e2-4331-893b-5de698f8a6d0/Patrick+Kerwin+B.jpg People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/32bbdb3f-d2bc-4dba-af0b-871dddf00d38/Prab+Mundi+B.jpg People https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/64db4587-6c4e-496d-968b-04eea3a14f9d/Aleks+Obradovic+B.jpg People https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/64a134a3-64c3-4209-b35a-5d6bfe60474b/Prem+Subramaniam+B.jpg People https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/4494bd23-1046-45a7-8759-3d5dc044e953/Mikko+Turunen+B.jpg People https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/b169af9a-5c7f-4872-a543-822ce4e6fd74/Gaetano%2BViscido%2BD.jpg People https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/b70f3360-1445-457a-8abb-4427467b47da/Cynthia+Tianxin+Wang+DSCF1870_.jpg.png People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/b21bc664-1246-435a-a35e-5bbefaabfb8b/Luca+Zanella+B.jpg People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/38f14381-6d91-42e2-b5e9-cf5066e0a09c/Mingxuan+Zhang%232++DSB_headshot.png People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. http://califano.c2b2.columbia.edu/n-of-1-clinical-trials-precision-medicine-cancer daily 0.75 2016-04-20 https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/1454411530958-0JASCBP8QNVAIF3B6XVR/image-asset.jpeg N-of-1 Clinical Trials and Precision Medicine Schematic of our approach to N-of-1 cancer clinical trials. Our goal is to identify existing FDA-approved and investigational compounds that could quickly be tested for effectiveness in blocking master regulators responsible for tumor maintenance. http://califano.c2b2.columbia.edu/home daily 1.0 2023-07-17 https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/1454434261950-XXMCIEPLIFIH45IGR0BM/image-asset.png Home https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/1456743534629-H8U0VTXIP7AP0F6GF75X/image-asset.jpeg Home https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/1456743697198-C0MRXGCEFRW0EI936Z0Q/image-asset.jpeg Home https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/1456743938864-F4IODPLSTRI59GPN9R63/image-asset.jpeg Home https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/1456743376568-UE5UC5FA4TR4LPG3HHB0/image-asset.jpeg Home https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/1456744156334-0CRIS2OXO8RL7ATZCZUV/image-asset.jpeg Home https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/1456744307872-58A0WCSA2RII91I4FJ30/image-asset.jpeg Home http://califano.c2b2.columbia.edu/software daily 0.75 2024-06-26 http://califano.c2b2.columbia.edu/drug-synergy-mechanism-of-action daily 0.75 2016-04-20 https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/1454403213723-L4449TBYZ1WWI1CFMOOY/image-asset.jpeg Drug Synergy and Mechanism of Action By analyzing drug-induced changes in disease-specific patterns of gene expression, a new algorithm called DeMAND identifies the genes involved in implementing a drug's effects. The method could help predict undesirable off-target interactions, suggest ways of regulating a drug's activity, and identify novel therapeutic uses for FDA-approved drugs, three critical challenges in drug development. http://califano.c2b2.columbia.edu/openings daily 0.75 2026-03-09 http://califano.c2b2.columbia.edu/research daily 0.75 2016-04-20 https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/1454434867062-MSAZ6AG1U1RAW2J8N1MD/image-asset.jpeg Research An algorithm developed in our lab called ARACNe uses gene expression data to identify transcriptional interactions. http://califano.c2b2.columbia.edu/aracne daily 0.75 2018-02-14 http://califano.c2b2.columbia.edu/networks daily 0.75 2016-04-18 http://califano.c2b2.columbia.edu/demand daily 0.75 2018-02-14 https://images.squarespace-cdn.com/content/v1/5697c2e5e0327ca6778bc453/1456485435951-CC8Q0B1P1SNUS8IP6770/image-asset.jpeg DeMAND http://califano.c2b2.columbia.edu/mindy2-cindy daily 0.75 2016-11-11 http://califano.c2b2.columbia.edu/cleaner daily 0.75 2016-06-20 http://califano.c2b2.columbia.edu/b-cell-interactome daily 0.75 2016-04-04 http://califano.c2b2.columbia.edu/splash daily 0.75 2016-04-05 http://califano.c2b2.columbia.edu/marina daily 0.75 2016-04-04 http://califano.c2b2.columbia.edu/bias-removal daily 0.75 2019-02-12 http://califano.c2b2.columbia.edu/viper daily 0.75 2018-02-14 http://califano.c2b2.columbia.edu/hermes daily 0.75 2016-04-05 http://califano.c2b2.columbia.edu/tcgaamltf daily 0.75 2016-04-06 http://califano.c2b2.columbia.edu/new-page-22 daily 0.75 2016-04-18 http://califano.c2b2.columbia.edu/downloads daily 0.75 2016-03-23 http://califano.c2b2.columbia.edu/form-test-page daily 0.75 2016-03-23 http://califano.c2b2.columbia.edu/aracne-license daily 0.75 2016-04-26 http://califano.c2b2.columbia.edu/marina-license daily 0.75 2016-04-04 http://califano.c2b2.columbia.edu/bias-removal-license daily 0.75 2016-04-04 http://califano.c2b2.columbia.edu/b-cell-interactome-license daily 0.75 2016-04-04 http://califano.c2b2.columbia.edu/demand-license daily 0.75 2016-04-04 http://califano.c2b2.columbia.edu/mindy2cindy-license daily 0.75 2016-04-05 http://califano.c2b2.columbia.edu/hermes-license daily 0.75 2016-04-04 http://califano.c2b2.columbia.edu/cleaner-license daily 0.75 2016-06-20 http://califano.c2b2.columbia.edu/splash-license daily 0.75 2016-04-04 http://califano.c2b2.columbia.edu/viper-license daily 0.75 2016-04-04 http://califano.c2b2.columbia.edu/brcamcf7-license daily 0.75 2016-04-18 http://califano.c2b2.columbia.edu/bcell-u95av2-license daily 0.75 2016-04-18 http://califano.c2b2.columbia.edu/bcellu133p2-license daily 0.75 2016-04-18 http://califano.c2b2.columbia.edu/tcgaamltf-license daily 0.75 2016-04-18 http://califano.c2b2.columbia.edu/media-contributions daily 0.75 2025-10-16